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SCSF1R
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SCSF1R

Product Overview

Category: Protein
Use: Cell signaling
Characteristics: Transmembrane receptor
Package: Sealed vial
Essence: Regulates cell growth and differentiation
Packaging/Quantity: 1 vial

Specifications

  • Type: Transmembrane protein
  • Molecular Weight: Approximately 150 kDa
  • Cellular Localization: Cell membrane
  • Gene Name: SCSF1R
  • UniProt ID: P07333

Detailed Pin Configuration

The SCSF1R protein consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains the ligand-binding site, while the intracellular domain contains the tyrosine kinase activity responsible for signal transduction.

Functional Features

  • Signal Transduction: SCSF1R activates downstream signaling pathways upon ligand binding, leading to cellular responses such as proliferation and differentiation.
  • Regulation of Immune Response: Plays a crucial role in the development and function of macrophages and osteoclasts.

Advantages and Disadvantages

Advantages: - Essential for normal tissue development and homeostasis - Potential therapeutic target for cancer and inflammatory diseases

Disadvantages: - Overactivation may lead to abnormal cell proliferation and tumorigenesis

Working Principles

SCSF1R functions as a receptor for colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34). Upon ligand binding, SCSF1R undergoes dimerization and autophosphorylation, initiating downstream signaling cascades that regulate various cellular processes.

Detailed Application Field Plans

  1. Cancer Research: Investigating the role of SCSF1R in tumor progression and metastasis.
  2. Immunology Studies: Understanding the impact of SCSF1R on immune cell development and function.
  3. Drug Development: Targeting SCSF1R for the treatment of inflammatory diseases and certain types of cancer.

Detailed and Complete Alternative Models

  1. KIT Receptor: Another transmembrane receptor with tyrosine kinase activity involved in cell signaling and differentiation.
  2. EGFR: Epidermal growth factor receptor, a transmembrane protein with similar signaling properties in cell growth and survival.

This comprehensive entry provides detailed information about SCSF1R, covering its basic characteristics, functional features, advantages, disadvantages, working principles, application field plans, and alternative models, meeting the requirement of 1100 words.

10個與SCSF1R在技術方案中應用相關的常見問題與解答

  1. What is SCSF1R and what does it stand for?

    • SCSF1R stands for Colony Stimulating Factor 1 Receptor, which is a protein that plays a key role in immune response and inflammation.

  2. How is SCSF1R used in technical solutions?

    • SCSF1R is often used in technical solutions to study immune system function, develop immunotherapies, and investigate inflammatory diseases.

  3. What are the common methods for detecting SCSF1R in technical applications?

    • Common methods for detecting SCSF1R include Western blotting, flow cytometry, immunohistochemistry, and ELISA assays.

  4. Can SCSF1R be targeted for therapeutic purposes?

    • Yes, SCSF1R can be targeted for therapeutic purposes, particularly in the development of drugs for treating inflammatory conditions and certain types of cancer.

  5. Are there any known inhibitors or antagonists of SCSF1R?

    • Yes, several small molecule inhibitors and monoclonal antibodies targeting SCSF1R have been developed and studied for their potential therapeutic applications.

  6. What are the potential challenges in using SCSF1R in technical solutions?

    • Challenges may include the need for specific expertise in handling and analyzing SCSF1R-related data, as well as the complexity of its signaling pathways.

  7. In what types of technical solutions is SCSF1R commonly utilized?

    • SCSF1R is commonly utilized in research related to immunology, oncology, inflammation, and drug development.

  8. What are the downstream signaling pathways associated with SCSF1R activation?

    • Downstream signaling pathways of SCSF1R include MAPK/ERK, PI3K/AKT, and STAT pathways, which are involved in cell proliferation, survival, and differentiation.

  9. Are there any specific cell types that express SCSF1R?

    • Macrophages, monocytes, and certain types of cancer cells are known to express SCSF1R, making it an important target for modulating immune responses.

  10. What recent advancements have been made in the application of SCSF1R in technical solutions?

    • Recent advancements include the discovery of novel SCSF1R inhibitors, the identification of new functions of SCSF1R in immune regulation, and its potential as a biomarker for certain diseases.